Evaluating Tissue Damage or Necrosis: Myocardial infarction (ESR rises within 24–48 hours post-event), Malignancies (e.g., lymphoma, multiple myeloma).
Screening for Hidden Pathologies: Unexplained fever, fatigue, or weight loss (ESR may indicate underlying inflammation). Giant cell arteritis (temporal arteritis) and polymyalgia rheumatica (diagnostic support).